Inference to the Best Explanation has become the subject of a livelydebate in the philosophy of science. Scientific realists maintain, while scientificantirealists deny, that it is a compelling rule of inference. It seems that anyattempt to settle this debate empirically must beg the question against theantirealist. The present paper argues that this impression is misleading. A methodis described that, by combining Glymour's theory of bootstrapping and Hacking'sarguments from microscopy, allows us to test IBE without begging any antirealistissues.